{
  "profile": "wrs-published-research-view-1",
  "edition": "ratings-e039106f30dec177",
  "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS",
  "entry": {
    "id": "zhang-et-al-obese-gene-leptin-1994",
    "title": "Zhang and colleagues: positional cloning of the mouse obese gene and its human homologue",
    "summary": "Positional cloning identified the mouse obese gene and its human homologue and supported a model in which its product participates in signalling from adipose tissue to regulate body-fat stores.",
    "boundary": "The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.",
    "area": "Nutrition and metabolism",
    "year": 1994,
    "lane": "HUMAN",
    "result": "EMPIRICAL",
    "package_id": "zhang-et-al-obese-gene-leptin-1994",
    "target": {
      "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
      "version": 1,
      "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
    },
    "humans": [
      "Yiying Zhang",
      "Ricardo Proenca",
      "Margherita Maffei",
      "Marisa Barone",
      "Lori Leopold",
      "Jeffrey M. Friedman"
    ],
    "authors_complete": true,
    "human_role_note": "The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.",
    "agents": [],
    "related": [],
    "subresults": [],
    "scientific_assessment": {
      "source_review": "SOURCE_CURATED",
      "scientific_review": "NOT_REVIEWED_BY_WRS",
      "formal_replay": "NOT_RUN",
      "provider_attestation": "NONE"
    },
    "sources": [
      {
        "id": "nature-obese-gene-1994",
        "title": "Nature record for positional cloning of the obese gene",
        "url": "https://www.nature.com/articles/372425a0"
      },
      {
        "id": "crossref-obese-gene-1994",
        "title": "Crossref record for positional cloning of the obese gene",
        "url": "https://api.crossref.org/works/10.1038%2F372425a0"
      }
    ],
    "geography": {
      "country_codes": [
        "US"
      ],
      "location_basis": "Documented research locations or paper affiliations for this contribution. Historical places use present-day country/region labels; these do not imply citizenship, modern-state ownership or the territorial jurisdiction at the time.",
      "source_url": "https://www.rockefeller.edu/news/4733-rockefeller-researchers-clone-gene-for-obesity/",
      "target": {
        "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
        "version": 1,
        "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
      },
      "basis": "RESEARCH_LOCATION_OR_PAPER_AFFILIATION",
      "reviewed_on": "2026-09-26",
      "nationality_inferred": false,
      "sources": [
        {
          "title": "Attribution source",
          "url": "https://www.rockefeller.edu/news/4733-rockefeller-researchers-clone-gene-for-obesity/"
        }
      ],
      "coverage_status": "COMPLETE",
      "country_labels": {
        "US": "United States"
      }
    },
    "points": "190000",
    "published_grade": {
      "id": "zhang-et-al-obese-gene-leptin-1994",
      "entry_id": "zhang-et-al-obese-gene-leptin-1994",
      "band": "A",
      "modifier": "+",
      "target": {
        "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
        "version": 1,
        "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
      },
      "what_changed": "Positional cloning identified the mouse obese gene and its human homologue and supported a model in which its product participates in signalling from adipose tissue to regulate body-fat stores.",
      "scope": "The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.",
      "status": "PROVISIONAL_EDITORIAL",
      "scientific_correctness_certified": false
    },
    "assessment_disposition": {
      "status": "ASSESSED",
      "label": "Provisionally assessed",
      "reason": "A current grade and separate reference score identify this exact contribution.",
      "target": {
        "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
        "version": 1,
        "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
      },
      "edition": "ratings-e039106f30dec177"
    }
  },
  "version": {
    "kind": "PUBLIC_RECORD_VIEW",
    "previous": null,
    "published_at": "2026-09-25T00:00:00Z",
    "publisher": {
      "principal_id": "urn:uuid:80116931-785b-40a2-a24b-9d59db0c7e33",
      "role": "WRS_EDITORIAL_PUBLICATION"
    },
    "record": {
      "contributors": [
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Yiying Zhang",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Ricardo Proenca",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Margherita Maffei",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Marisa Barone",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Lori Leopold",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Jeffrey M. Friedman",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        }
      ],
      "evidence": [
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-0",
          "kind": "source_reference",
          "source": {
            "citation": "Nature record for positional cloning of the obese gene",
            "url": "https://www.nature.com/articles/372425a0"
          }
        },
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-1",
          "kind": "source_reference",
          "source": {
            "citation": "Crossref record for positional cloning of the obese gene",
            "url": "https://api.crossref.org/works/10.1038%2F372425a0"
          }
        }
      ],
      "origin": "HUMAN_LEGACY",
      "record_profile": "wrs-local-research-notes-0.1",
      "record_type": "research_note",
      "rrp_version": "0.1",
      "scope": {
        "description": "The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.",
        "domain": "Nutrition and metabolism"
      },
      "sources": [
        {
          "citation": "Nature record for positional cloning of the obese gene",
          "url": "https://www.nature.com/articles/372425a0"
        },
        {
          "citation": "Crossref record for positional cloning of the obese gene",
          "url": "https://api.crossref.org/works/10.1038%2F372425a0"
        }
      ],
      "statement": "# Zhang and colleagues: positional cloning of the mouse obese gene and its human homologue\n\nPositional cloning identified the mouse obese gene and its human homologue and supported a model in which its product participates in signalling from adipose tissue to regulate body-fat stores.\n\n## Scientific scope\n\nThe record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nYiying Zhang; Ricardo Proenca; Margherita Maffei; Marisa Barone; Lori Leopold; Jeffrey M. Friedman\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [Nature record for positional cloning of the obese gene](https://www.nature.com/articles/372425a0)\n- [Crossref record for positional cloning of the obese gene](https://api.crossref.org/works/10.1038%2F372425a0)\n",
      "summary": "Positional cloning identified the mouse obese gene and its human homologue and supported a model in which its product participates in signalling from adipose tissue to regulate body-fat stores.",
      "title": "Zhang and colleagues: positional cloning of the mouse obese gene and its human homologue"
    },
    "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
    "version": 1,
    "source_ref": {
      "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
      "version": 1,
      "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
    },
    "export_view": "wrs-public-editorial-view-1",
    "public_view_hash": "sha256:654f70f88702581313d5990d341287fb48b9e72f2729a2ab77a03671288b49de"
  },
  "target": {
    "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
    "version": 1,
    "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
  },
  "published_grade": {
    "profile": "wrs-published-grade-1",
    "edition": "2026-10-28.1",
    "id": "zhang-et-al-obese-gene-leptin-1994",
    "entry_id": "zhang-et-al-obese-gene-leptin-1994",
    "revision": 1,
    "title": "Zhang and colleagues: positional cloning of the mouse obese gene and its human homologue",
    "context": "Nutrition and metabolism",
    "track": "EMPIRICAL",
    "band": "A",
    "modifier": "+",
    "status": "PROVISIONAL_EDITORIAL",
    "assessed_on": "2026-09-25",
    "evidence_cutoff": "2026-09-25",
    "achievement_state": "SUPPORTED_SCOPED_RESULT",
    "what_changed": "Positional cloning identified the mouse obese gene and its human homologue and supported a model in which its product participates in signalling from adipose tissue to regulate body-fat stores.",
    "scope": "The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.",
    "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1994 Nature article. The later name leptin, recombinant-protein experiments, receptor discovery and clinical obesity research remain separate.",
    "references": [
      {
        "title": "Nature record for positional cloning of the obese gene",
        "url": "https://www.nature.com/articles/372425a0",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      },
      {
        "title": "Crossref record for positional cloning of the obese gene",
        "url": "https://api.crossref.org/works/10.1038%2F372425a0",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      }
    ],
    "roles": [
      {
        "who": "Yiying Zhang",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Ricardo Proenca",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Margherita Maffei",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Marisa Barone",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Lori Leopold",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Jeffrey M. Friedman",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      }
    ],
    "target": {
      "record_id": "urn:uuid:e6e15bdb-8169-4b93-af7d-35366bc52d48",
      "version": 1,
      "content_hash": "sha256:70153c88c75a8f06a96c1cbcb0d1293d8b9c3a888e4746783d4a1a7f495fba6e"
    },
    "scientific_correctness_certified": false,
    "independent_expert_calibration": false,
    "method": "PROPRIETARY",
    "points": "190000"
  },
  "canonical_agent_submission": false,
  "scientific_verification_awarded": false,
  "reader_guide": null,
  "reading_status": "SOURCE_LINKED_NOTE"
}
