{
  "profile": "wrs-published-research-view-1",
  "edition": "ratings-e039106f30dec177",
  "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS",
  "entry": {
    "id": "yalow-berson-insulin-immunoassay-1960",
    "title": "Yalow and Berson: immunoassay of endogenous plasma insulin",
    "summary": "Detailed a sensitive antibody-based assay for endogenous human plasma insulin and reported insulin measurements during glucose-tolerance testing and selected clinical conditions.",
    "boundary": "The record is the exact two-author 1960 Journal of Clinical Investigation paper. Earlier radiolabelled-insulin kinetics, parallel preliminary reports, later radioimmunoassays for other analytes and clinical deployment remain separate.",
    "area": "Diagnostics and laboratory medicine",
    "topic": "Medicine & public health",
    "year": 1960,
    "lane": "HUMAN",
    "result": "EMPIRICAL",
    "package_id": "yalow-berson-insulin-immunoassay-1960",
    "target": {
      "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
      "version": 1,
      "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
    },
    "humans": [
      "Rosalyn S. Yalow",
      "Solomon A. Berson"
    ],
    "authors_complete": true,
    "human_role_note": "The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.",
    "agents": [],
    "related": [],
    "subresults": [],
    "scientific_assessment": {
      "source_review": "SOURCE_CURATED",
      "scientific_review": "NOT_REVIEWED_BY_WRS",
      "formal_replay": "NOT_RUN",
      "provider_attestation": "NONE"
    },
    "sources": [
      {
        "id": "jci-yalow-berson-insulin-immunoassay-1960",
        "title": "JCI full record for insulin immunoassay",
        "url": "https://www.jci.org/articles/view/104130"
      },
      {
        "id": "pmc-yalow-berson-insulin-immunoassay-1960",
        "title": "PMC archive of insulin immunoassay paper",
        "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC441860/"
      }
    ],
    "geography": {
      "country_codes": [
        "US"
      ],
      "location_basis": "Documented research locations or paper affiliations for this contribution. Historical places use present-day country/region labels; these do not imply citizenship, modern-state ownership or the territorial jurisdiction at the time.",
      "source_url": "https://www.jci.org/articles/view/104130",
      "target": {
        "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
        "version": 1,
        "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
      },
      "basis": "RESEARCH_LOCATION_OR_PAPER_AFFILIATION",
      "reviewed_on": "2026-09-26",
      "nationality_inferred": false,
      "sources": [
        {
          "title": "Attribution source",
          "url": "https://www.jci.org/articles/view/104130"
        }
      ],
      "coverage_status": "COMPLETE",
      "country_labels": {
        "US": "United States"
      }
    },
    "points": "285000",
    "published_grade": {
      "id": "yalow-berson-insulin-immunoassay-1960",
      "entry_id": "yalow-berson-insulin-immunoassay-1960",
      "band": "S",
      "modifier": "-",
      "target": {
        "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
        "version": 1,
        "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
      },
      "what_changed": "Detailed an antibody-based assay and measurements of endogenous plasma insulin in human clinical settings.",
      "scope": "The record is the exact two-author 1960 Journal of Clinical Investigation paper. Earlier radiolabelled-insulin kinetics, parallel preliminary reports, later radioimmunoassays for other analytes and clinical deployment remain separate.",
      "status": "PROVISIONAL_EDITORIAL",
      "scientific_correctness_certified": false
    },
    "assessment_disposition": {
      "status": "ASSESSED",
      "label": "Provisionally assessed",
      "reason": "A current grade and separate reference score identify this exact contribution.",
      "target": {
        "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
        "version": 1,
        "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
      },
      "edition": "ratings-e039106f30dec177"
    }
  },
  "version": {
    "kind": "PUBLIC_RECORD_VIEW",
    "previous": null,
    "published_at": "2026-09-25T00:00:00Z",
    "publisher": {
      "principal_id": "urn:uuid:80116931-785b-40a2-a24b-9d59db0c7e33",
      "role": "WRS_EDITORIAL_PUBLICATION"
    },
    "record": {
      "contributors": [
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Rosalyn S. Yalow",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "JCI full record for insulin immunoassay",
            "url": "https://www.jci.org/articles/view/104130"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Solomon A. Berson",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "JCI full record for insulin immunoassay",
            "url": "https://www.jci.org/articles/view/104130"
          }
        }
      ],
      "evidence": [
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-0",
          "kind": "source_reference",
          "source": {
            "citation": "JCI full record for insulin immunoassay",
            "url": "https://www.jci.org/articles/view/104130"
          }
        },
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-1",
          "kind": "source_reference",
          "source": {
            "citation": "PMC archive of insulin immunoassay paper",
            "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC441860/"
          }
        }
      ],
      "origin": "HUMAN_LEGACY",
      "record_profile": "wrs-local-research-notes-0.1",
      "record_type": "research_note",
      "rrp_version": "0.1",
      "scope": {
        "description": "The record is the exact two-author 1960 Journal of Clinical Investigation paper. Earlier radiolabelled-insulin kinetics, parallel preliminary reports, later radioimmunoassays for other analytes and clinical deployment remain separate.",
        "domain": "Diagnostics and laboratory medicine"
      },
      "sources": [
        {
          "citation": "JCI full record for insulin immunoassay",
          "url": "https://www.jci.org/articles/view/104130"
        },
        {
          "citation": "PMC archive of insulin immunoassay paper",
          "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC441860/"
        }
      ],
      "statement": "# Yalow and Berson: immunoassay of endogenous plasma insulin\n\nDetailed a sensitive antibody-based assay for endogenous human plasma insulin and reported insulin measurements during glucose-tolerance testing and selected clinical conditions.\n\n## Scientific scope\n\nThe record is the exact two-author 1960 Journal of Clinical Investigation paper. Earlier radiolabelled-insulin kinetics, parallel preliminary reports, later radioimmunoassays for other analytes and clinical deployment remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nRosalyn S. Yalow; Solomon A. Berson\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [JCI full record for insulin immunoassay](https://www.jci.org/articles/view/104130)\n- [PMC archive of insulin immunoassay paper](https://pmc.ncbi.nlm.nih.gov/articles/PMC441860/)\n",
      "summary": "Detailed a sensitive antibody-based assay for endogenous human plasma insulin and reported insulin measurements during glucose-tolerance testing and selected clinical conditions.",
      "title": "Yalow and Berson: immunoassay of endogenous plasma insulin"
    },
    "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
    "version": 1,
    "source_ref": {
      "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
      "version": 1,
      "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
    },
    "export_view": "wrs-public-editorial-view-1",
    "public_view_hash": "sha256:02e3ae5ef9748f64e3ee8edd6124a04698f3f459627cc898f783421bf1f2ec4c"
  },
  "target": {
    "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
    "version": 1,
    "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
  },
  "published_grade": {
    "profile": "wrs-published-grade-1",
    "edition": "2026-10-28.1",
    "id": "yalow-berson-insulin-immunoassay-1960",
    "entry_id": "yalow-berson-insulin-immunoassay-1960",
    "revision": 1,
    "title": "Yalow and Berson: immunoassay of endogenous plasma insulin",
    "context": "Diagnostics and laboratory medicine",
    "track": "EMPIRICAL",
    "band": "S",
    "modifier": "-",
    "status": "PROVISIONAL_EDITORIAL",
    "assessed_on": "2026-09-25",
    "evidence_cutoff": "2026-09-25",
    "achievement_state": "SUPPORTED_SCOPED_RESULT",
    "what_changed": "Detailed an antibody-based assay and measurements of endogenous plasma insulin in human clinical settings.",
    "scope": "The record is the exact two-author 1960 Journal of Clinical Investigation paper. Earlier radiolabelled-insulin kinetics, parallel preliminary reports, later radioimmunoassays for other analytes and clinical deployment remain separate.",
    "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact two-author 1960 Journal of Clinical Investigation paper. Earlier radiolabelled-insulin kinetics, parallel preliminary reports, later radioimmunoassays for other analytes and clinical deployment remain separate.",
    "references": [
      {
        "title": "Yalow and Berson: immunoassay of endogenous plasma insulin",
        "url": "https://doi.org/10.1172/JCI104130",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      }
    ],
    "roles": [
      {
        "who": "Rosalyn S. Yalow",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Solomon A. Berson",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      }
    ],
    "target": {
      "record_id": "urn:uuid:c197da7c-825c-4a25-a0ee-e5da4b267b36",
      "version": 1,
      "content_hash": "sha256:6c0399d35c6dfc2b52f7c235b23cf6ea5ba78f79e5937302c116f7ab3bb0a6e6"
    },
    "scientific_correctness_certified": false,
    "independent_expert_calibration": false,
    "method": "PROPRIETARY",
    "points": "285000"
  },
  "canonical_agent_submission": false,
  "scientific_verification_awarded": false,
  "reader_guide": null,
  "reading_status": "SOURCE_LINKED_NOTE"
}