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      "statement": "# Ondetti, Rubin and Cushman: orally active ACE inhibitors\n\nReported a model-guided design of potent angiotensin-converting-enzyme inhibitors and animal experiments showing oral inhibition of angiotensin-I responses and lowered blood pressure in a renovascular-hypertension model.\n\n## Scientific scope\n\nThe record is the exact 1977 Science paper and its preclinical experiments. Earlier venom peptides, subsequent human captopril trials, regulatory approval, other ACE inhibitors and population-level outcome claims remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nMiguel A. Ondetti; Bernard Rubin; David W. Cushman\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [PubMed record for orally active ACE inhibitors](https://pubmed.ncbi.nlm.nih.gov/191908/)\n- [Crossref record for orally active ACE inhibitors](https://api.crossref.org/works/10.1126%2Fscience.191908)\n",
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