{ "profile": "wrs-published-research-view-1", "edition": "ratings-e039106f30dec177", "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS", "entry": { "id": "marshall-et-al-pylori-eradication-ulcer-relapse-1988", "title": "Marshall and colleagues: pylori eradication and duodenal-ulcer relapse", "summary": "In a prospective double-blind trial of 100 infected patients with duodenal ulcer, linked bacterial clearance under the tested regimens to higher healing and substantially lower twelve-month relapse.", "boundary": "The record is the exact nine-author 1988 Lancet trial. Results are bounded to the enrolled population, regimens, bacterial classification and follow-up; the earlier organism observation, later Helicobacter nomenclature and modern eradication standards remain separate.", "area": "Infectious disease and microbiology", "year": 1988, "lane": "HUMAN", "result": "EMPIRICAL", "package_id": "marshall-et-al-pylori-eradication-ulcer-relapse-1988", "target": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "humans": [ "Barry J. Marshall", "C. Stewart Goodwin", "J. Robin Warren", "Raymond Murray", "Elizabeth D. Blincow", "Stephen J. Blackbourn", "Michael Phillips", "Thomas E. Waters", "Christopher R. Sanderson" ], "authors_complete": true, "human_role_note": "The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.", "agents": [], "related": [], "subresults": [], "scientific_assessment": { "source_review": "SOURCE_CURATED", "scientific_review": "NOT_REVIEWED_BY_WRS", "formal_replay": "NOT_RUN", "provider_attestation": "NONE" }, "sources": [ { "id": "pubmed-marshall-pylori-eradication-1988", "title": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" }, { "id": "crossref-marshall-pylori-eradication-1988", "title": "Crossref metadata for pylori-eradication trial", "url": "https://api.crossref.org/works/10.1016%2FS0140-6736%2888%2990929-4" } ], "geography": { "country_codes": [ "AU" ], "location_basis": "Documented research locations or paper affiliations for this contribution. Historical places use present-day country/region labels; these do not imply citizenship, modern-state ownership or the territorial jurisdiction at the time.", "source_url": "https://www.researchgate.net/publication/20250827_Prospective_double-blind_trial_of_duodenal_relapse_after_eradication_of_Campylobacter_pylori", "target": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "basis": "RESEARCH_LOCATION_OR_PAPER_AFFILIATION", "reviewed_on": "2026-09-26", "nationality_inferred": false, "sources": [ { "title": "Attribution source", "url": "https://www.researchgate.net/publication/20250827_Prospective_double-blind_trial_of_duodenal_relapse_after_eradication_of_Campylobacter_pylori" }, { "title": "Attribution source", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } ], "coverage_status": "COMPLETE", "country_labels": { "AU": "Australia" } }, "points": "190000", "published_grade": { "id": "marshall-et-al-pylori-eradication-ulcer-relapse-1988", "entry_id": "marshall-et-al-pylori-eradication-ulcer-relapse-1988", "band": "A", "modifier": "+", "target": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "what_changed": "In a prospective double-blind 100-patient study, related eradication under tested regimens to healing and lower duodenal-ulcer relapse.", "scope": "The record is the exact nine-author 1988 Lancet trial. Results are bounded to the enrolled population, regimens, bacterial classification and follow-up; the earlier organism observation, later Helicobacter nomenclature and modern eradication standards remain separate.", "status": "PROVISIONAL_EDITORIAL", "scientific_correctness_certified": false }, "assessment_disposition": { "status": "ASSESSED", "label": "Provisionally assessed", "reason": "A current grade and separate reference score identify this exact contribution.", "target": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "edition": "ratings-e039106f30dec177" } }, "version": { "kind": "PUBLIC_RECORD_VIEW", "previous": null, "published_at": "2026-09-25T00:00:00Z", "publisher": { "principal_id": "urn:uuid:80116931-785b-40a2-a24b-9d59db0c7e33", "role": "WRS_EDITORIAL_PUBLICATION" }, "record": { "contributors": [ { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Barry J. Marshall", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "C. Stewart Goodwin", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "J. Robin Warren", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Raymond Murray", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Elizabeth D. Blincow", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Stephen J. Blackbourn", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Michael Phillips", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Thomas E. Waters", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Christopher R. Sanderson", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } } ], "evidence": [ { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-0", "kind": "source_reference", "source": { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" } }, { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-1", "kind": "source_reference", "source": { "citation": "Crossref metadata for pylori-eradication trial", "url": "https://api.crossref.org/works/10.1016%2FS0140-6736%2888%2990929-4" } } ], "origin": "HUMAN_LEGACY", "record_profile": "wrs-local-research-notes-0.1", "record_type": "research_note", "rrp_version": "0.1", "scope": { "description": "The record is the exact nine-author 1988 Lancet trial. Results are bounded to the enrolled population, regimens, bacterial classification and follow-up; the earlier organism observation, later Helicobacter nomenclature and modern eradication standards remain separate.", "domain": "Infectious disease and microbiology" }, "sources": [ { "citation": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/" }, { "citation": "Crossref metadata for pylori-eradication trial", "url": "https://api.crossref.org/works/10.1016%2FS0140-6736%2888%2990929-4" } ], "statement": "# Marshall and colleagues: pylori eradication and duodenal-ulcer relapse\n\nIn a prospective double-blind trial of 100 infected patients with duodenal ulcer, linked bacterial clearance under the tested regimens to higher healing and substantially lower twelve-month relapse.\n\n## Scientific scope\n\nThe record is the exact nine-author 1988 Lancet trial. Results are bounded to the enrolled population, regimens, bacterial classification and follow-up; the earlier organism observation, later Helicobacter nomenclature and modern eradication standards remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nBarry J. Marshall; C. Stewart Goodwin; J. Robin Warren; Raymond Murray; Elizabeth D. Blincow; Stephen J. Blackbourn; Michael Phillips; Thomas E. Waters; Christopher R. Sanderson\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [PubMed record and abstract for pylori-eradication trial](https://pubmed.ncbi.nlm.nih.gov/2904568/)\n- [Crossref metadata for pylori-eradication trial](https://api.crossref.org/works/10.1016%2FS0140-6736%2888%2990929-4)\n", "summary": "In a prospective double-blind trial of 100 infected patients with duodenal ulcer, linked bacterial clearance under the tested regimens to higher healing and substantially lower twelve-month relapse.", "title": "Marshall and colleagues: pylori eradication and duodenal-ulcer relapse" }, "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "source_ref": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:f026abea0f1aecd6bf1e8a5882a7a60aceb60129832354f6617f10026ec06487" }, "target": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "marshall-et-al-pylori-eradication-ulcer-relapse-1988", "entry_id": "marshall-et-al-pylori-eradication-ulcer-relapse-1988", "revision": 1, "title": "Marshall and colleagues: pylori eradication and duodenal-ulcer relapse", "context": "Infectious disease and microbiology", "track": "METHOD", "band": "A", "modifier": "+", "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-25", "evidence_cutoff": "2026-09-25", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "In a prospective double-blind 100-patient study, related eradication under tested regimens to healing and lower duodenal-ulcer relapse.", "scope": "The record is the exact nine-author 1988 Lancet trial. Results are bounded to the enrolled population, regimens, bacterial classification and follow-up; the earlier organism observation, later Helicobacter nomenclature and modern eradication standards remain separate.", "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact nine-author 1988 Lancet trial. Results are bounded to the enrolled population, regimens, bacterial classification and follow-up; the earlier organism observation, later Helicobacter nomenclature and modern eradication standards remain separate.", "references": [ { "title": "PubMed record and abstract for pylori-eradication trial", "url": "https://pubmed.ncbi.nlm.nih.gov/2904568/", "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work." }, { "title": "Crossref metadata for pylori-eradication trial", "url": "https://api.crossref.org/works/10.1016%2FS0140-6736%2888%2990929-4", "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work." } ], "roles": [ { "who": "Barry J. Marshall", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "C. Stewart Goodwin", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "J. Robin Warren", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Raymond Murray", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Elizabeth D. Blincow", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Stephen J. Blackbourn", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Michael Phillips", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Thomas E. Waters", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Christopher R. Sanderson", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." } ], "target": { "record_id": "urn:uuid:75be58e1-8cc9-44a1-a3ed-61871bd5d2b8", "version": 1, "content_hash": "sha256:1739898ea5aa7aa168afd25c675235499580f09333a39651e57efd4f01387ffa" }, "scientific_correctness_certified": false, "independent_expert_calibration": false, "method": "PROPRIETARY", "points": "190000" }, "canonical_agent_submission": false, "scientific_verification_awarded": false, "reader_guide": null, "reading_status": "SOURCE_LINKED_NOTE" }