{ "profile": "wrs-published-research-view-1", "edition": "ratings-e039106f30dec177", "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS", "entry": { "id": "lawitz-sofosbuvir-untreated-hcv-2013", "title": "Lawitz and colleagues: sofosbuvir regimens for previously untreated hepatitis C", "summary": "Reported phase 3 clinical evidence for sofosbuvir-based regimens in previously untreated chronic hepatitis C across multiple viral genotypes, measuring sustained virologic response after therapy.", "boundary": "The record is the exact 2013 NEJM article and its two open-label trials, regimens and populations. 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Gordon", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Michael Schultz", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Mitchell N. Davis", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Zeid Kayali", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "K. 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Kowdley", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Lisa Nyberg", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "G. Mani Subramanian", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Robert H. Hyland", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Sarah Arterburn", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Deyuan Jiang", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "John McNally", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Diana Brainard", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "William T. 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Sheikh", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Zobair Younossi", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Edward J. Gane", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } } ], "evidence": [ { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-0", "kind": "source_reference", "source": { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" } }, { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-1", "kind": "source_reference", "source": { "citation": "Crossref record for sofosbuvir in untreated HCV", "url": "https://api.crossref.org/works/10.1056%2FNEJMoa1214853" } } ], "origin": "HUMAN_LEGACY", "record_profile": "wrs-local-research-notes-0.1", "record_type": "research_note", "rrp_version": "0.1", "scope": { "description": "The record is the exact 2013 NEJM article and its two open-label trials, regimens and populations. HCV discovery, sofosbuvir chemistry, later interferon-free combinations, approvals, elimination programmes and all HCV genotypes remain separate.", "domain": "Infectious disease and microbiology" }, "sources": [ { "citation": "Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1214853" }, { "citation": "Crossref record for sofosbuvir in untreated HCV", "url": "https://api.crossref.org/works/10.1056%2FNEJMoa1214853" } ], "statement": "# Lawitz and colleagues: sofosbuvir regimens for previously untreated hepatitis C\n\nReported phase 3 clinical evidence for sofosbuvir-based regimens in previously untreated chronic hepatitis C across multiple viral genotypes, measuring sustained virologic response after therapy.\n\n## Scientific scope\n\nThe record is the exact 2013 NEJM article and its two open-label trials, regimens and populations. HCV discovery, sofosbuvir chemistry, later interferon-free combinations, approvals, elimination programmes and all HCV genotypes remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nEric Lawitz; Alessandra Mangia; David Wyles; Maribel Rodriguez-Torres; Tarek Hassanein; Stuart C. Gordon; Michael Schultz; Mitchell N. Davis; Zeid Kayali; K. Rajender Reddy; Ira M. Jacobson; Kris V. Kowdley; Lisa Nyberg; G. Mani Subramanian; Robert H. Hyland; Sarah Arterburn; Deyuan Jiang; John McNally; Diana Brainard; William T. Symonds; John G. McHutchison; Aasim M. Sheikh; Zobair Younossi; Edward J. Gane\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [Lawitz et al., Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection](https://www.nejm.org/doi/full/10.1056/NEJMoa1214853)\n- [Crossref record for sofosbuvir in untreated HCV](https://api.crossref.org/works/10.1056%2FNEJMoa1214853)\n", "summary": "Reported phase 3 clinical evidence for sofosbuvir-based regimens in previously untreated chronic hepatitis C across multiple viral genotypes, measuring sustained virologic response after therapy.", "title": "Lawitz and colleagues: sofosbuvir regimens for previously untreated hepatitis C" }, "record_id": "urn:uuid:66a962e6-e574-4a3d-a4b7-3fc99a151f64", "version": 1, "source_ref": { "record_id": "urn:uuid:66a962e6-e574-4a3d-a4b7-3fc99a151f64", "version": 1, "content_hash": "sha256:8d31f6c28bfda3ca3169b2e4cb6ca0459c5404529ad1b78f420fc69bb7acd771" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:0d29c4897484398ae8a4eef2ac49c68b0257bc7184f608dcced1623dfbfc951a" }, "target": { "record_id": "urn:uuid:66a962e6-e574-4a3d-a4b7-3fc99a151f64", "version": 1, "content_hash": "sha256:8d31f6c28bfda3ca3169b2e4cb6ca0459c5404529ad1b78f420fc69bb7acd771" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "lawitz-sofosbuvir-untreated-hcv-2013", "entry_id": "lawitz-sofosbuvir-untreated-hcv-2013", "revision": 1, "title": "Lawitz and colleagues: sofosbuvir regimens for previously untreated hepatitis C", "context": "Infectious disease", "track": "Clinical trial evidence", "band": "A", "modifier": null, "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-25", "evidence_cutoff": "2026-09-25", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "Sofosbuvir-based treatment gained pivotal genotype-specific clinical evidence.", "scope": "Exact 24-author 2013 article and two trials; later interferon-free combinations/approval/elimination separate.", "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 2013 NEJM article and its two open-label trials, regimens and populations. 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