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A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nWilliam B. Kannel; Thomas R. Dawber; Abraham Kagan; Nicholas Revotskie; Joseph Stokes III\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [Kannel et al., Factors of Risk in the Development of Coronary Heart Disease](https://pubmed.ncbi.nlm.nih.gov/13751193/)\n- [Kannel et al. 1961 Framingham paper copy](https://laoha.org/wp-content/uploads/2024/01/Framingham.pdf)\n", "summary": "Used six-year prospective follow-up to relate baseline characteristics including blood pressure and serum cholesterol to later coronary heart disease and to frame multivariable risk identification.", "title": "Kannel and colleagues: coronary risk in the Framingham Study" }, "record_id": "urn:uuid:afcd29ba-ad3f-4725-a24e-f3a2e0172de4", "version": 1, "source_ref": { "record_id": "urn:uuid:afcd29ba-ad3f-4725-a24e-f3a2e0172de4", "version": 1, "content_hash": "sha256:996a8857b0c63d5ead827af338146b8759bf0eb120ad777ffcff263d67088378" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:1c36e24711fc074ce7edcebeb6b4306af1e6780e723dbef4db024cae5b89a50a" }, "target": { "record_id": "urn:uuid:afcd29ba-ad3f-4725-a24e-f3a2e0172de4", "version": 1, "content_hash": "sha256:996a8857b0c63d5ead827af338146b8759bf0eb120ad777ffcff263d67088378" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "kannel-et-al-framingham-risk-1961", "entry_id": "kannel-et-al-framingham-risk-1961", "revision": 1, "title": "Kannel and colleagues: coronary risk in the Framingham Study", "context": "Epidemiology", "track": "Prospective risk-factor evidence", "band": "A", "modifier": "+", "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-25", "evidence_cutoff": "2026-09-25", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "Prospective cohort data gave a systematic basis for identifying coronary risk factors.", "scope": "Exact 1961 five-author paper; observational risk association, not randomized proof of treatment benefit or universal causation.", "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The study identifies associations useful for risk prediction; it is not itself a randomized treatment trial and does not establish that every measured factor is independently causal.", "references": [ { "title": "Kannel et al., Factors of Risk in the Development of Coronary Heart Disease", "url": "https://pubmed.ncbi.nlm.nih.gov/13751193/", "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work." }, { "title": "Kannel et al. 1961 Framingham paper copy", "url": "https://laoha.org/wp-content/uploads/2024/01/Framingham.pdf", "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work." } ], "roles": [ { "who": "William B. Kannel", "credit": "SCIENCE", "did": "Named source author of the scoped work; individual effort shares are not measured." }, { "who": "Thomas R. 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