{
  "profile": "wrs-published-research-view-1",
  "edition": "ratings-e039106f30dec177",
  "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS",
  "entry": {
    "id": "gey-hela-continuous-cell-culture-1952",
    "title": "Gey, Coffman and Kubicek: continuous culture of the HeLa cervical-carcinoma strain",
    "summary": "Reported an in-vitro comparison of cervical tissues and described one epidermoid-carcinoma strain maintained in continuous roller-tube culture for almost a year.",
    "boundary": "The record is the exact 1952 Cancer Research proceedings paper. Henrietta Lacks’s tissue contribution, the absence of her knowledge or consent, later HeLa distribution, cell-line applications and subsequent discoveries remain separate.",
    "area": "Anatomy, physiology and pathology",
    "year": 1952,
    "lane": "HUMAN",
    "result": "EMPIRICAL",
    "package_id": "gey-hela-continuous-cell-culture-1952",
    "target": {
      "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
      "version": 1,
      "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
    },
    "humans": [
      "George Otto Gey",
      "Ward D. Coffman",
      "Mary Toye Kubicek"
    ],
    "authors_complete": true,
    "human_role_note": "The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.",
    "agents": [],
    "related": [],
    "subresults": [],
    "scientific_assessment": {
      "source_review": "SOURCE_CURATED",
      "scientific_review": "NOT_REVIEWED_BY_WRS",
      "formal_replay": "NOT_RUN",
      "provider_attestation": "NONE"
    },
    "sources": [
      {
        "id": "cellosaurus-gey-hela-1952",
        "title": "Cellosaurus publication record for Gey, Coffman and Kubicek",
        "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
      },
      {
        "id": "aacr-cancer-research-1952-issue",
        "title": "Cancer Research volume 12 issue 4",
        "url": "https://aacrjournals.org/cancerres/issue/12/4"
      },
      {
        "id": "nih-lacks-family-agreement",
        "title": "NIH–Lacks Family Agreement and HeLa history",
        "url": "https://www.grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/dms/privacy/nih-lacks-family-agreement"
      }
    ],
    "geography": {
      "country_codes": [
        "US"
      ],
      "location_basis": "Documented research locations or paper affiliations for this contribution. Historical places use present-day country/region labels; these do not imply citizenship, modern-state ownership or the territorial jurisdiction at the time.",
      "source_url": "https://phylogenomics.me/2011/09/07/fun-with-pubmed-central-first-paper-describing-hela-cells-note-rebeccaskloot/",
      "target": {
        "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
        "version": 1,
        "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
      },
      "basis": "RESEARCH_LOCATION_OR_PAPER_AFFILIATION",
      "reviewed_on": "2026-09-26",
      "nationality_inferred": false,
      "sources": [
        {
          "title": "Attribution source",
          "url": "https://phylogenomics.me/2011/09/07/fun-with-pubmed-central-first-paper-describing-hela-cells-note-rebeccaskloot/"
        },
        {
          "title": "Attribution source",
          "url": "https://www.hopkinsmedicine.org/henrietta-lacks/role-of-the-johns-hopkins-hospital"
        },
        {
          "title": "Attribution source",
          "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
        }
      ],
      "coverage_status": "COMPLETE",
      "country_labels": {
        "US": "United States"
      }
    },
    "points": "165000",
    "published_grade": {
      "id": "gey-hela-continuous-cell-culture-1952",
      "entry_id": "gey-hela-continuous-cell-culture-1952",
      "band": "A",
      "modifier": "+",
      "target": {
        "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
        "version": 1,
        "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
      },
      "what_changed": "A continuously propagating human cancer-cell strain was available for laboratory research.",
      "scope": "Gey, Coffman and Kubicek's 1952 note; tissue donor Henrietta Lacks, later distribution and uses distinct.",
      "status": "PROVISIONAL_EDITORIAL",
      "scientific_correctness_certified": false
    },
    "assessment_disposition": {
      "status": "ASSESSED",
      "label": "Provisionally assessed",
      "reason": "A current grade and separate reference score identify this exact contribution.",
      "target": {
        "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
        "version": 1,
        "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
      },
      "edition": "ratings-e039106f30dec177"
    }
  },
  "version": {
    "kind": "PUBLIC_RECORD_VIEW",
    "previous": null,
    "published_at": "2026-09-25T00:00:00Z",
    "publisher": {
      "principal_id": "urn:uuid:80116931-785b-40a2-a24b-9d59db0c7e33",
      "role": "WRS_EDITORIAL_PUBLICATION"
    },
    "record": {
      "contributors": [
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "George Otto Gey",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Cellosaurus publication record for Gey, Coffman and Kubicek",
            "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Ward D. Coffman",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Cellosaurus publication record for Gey, Coffman and Kubicek",
            "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Mary Toye Kubicek",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "Cellosaurus publication record for Gey, Coffman and Kubicek",
            "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
          }
        }
      ],
      "evidence": [
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-0",
          "kind": "source_reference",
          "source": {
            "citation": "Cellosaurus publication record for Gey, Coffman and Kubicek",
            "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
          }
        },
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-1",
          "kind": "source_reference",
          "source": {
            "citation": "Cancer Research volume 12 issue 4",
            "url": "https://aacrjournals.org/cancerres/issue/12/4"
          }
        },
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-2",
          "kind": "source_reference",
          "source": {
            "citation": "NIH–Lacks Family Agreement and HeLa history",
            "url": "https://www.grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/dms/privacy/nih-lacks-family-agreement"
          }
        }
      ],
      "origin": "HUMAN_LEGACY",
      "record_profile": "wrs-local-research-notes-0.1",
      "record_type": "research_note",
      "rrp_version": "0.1",
      "scope": {
        "description": "The record is the exact 1952 Cancer Research proceedings paper. Henrietta Lacks’s tissue contribution, the absence of her knowledge or consent, later HeLa distribution, cell-line applications and subsequent discoveries remain separate.",
        "domain": "Anatomy, physiology and pathology"
      },
      "sources": [
        {
          "citation": "Cellosaurus publication record for Gey, Coffman and Kubicek",
          "url": "https://www.cellosaurus.org/cellopub/CLPUB00047"
        },
        {
          "citation": "Cancer Research volume 12 issue 4",
          "url": "https://aacrjournals.org/cancerres/issue/12/4"
        },
        {
          "citation": "NIH–Lacks Family Agreement and HeLa history",
          "url": "https://www.grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/dms/privacy/nih-lacks-family-agreement"
        }
      ],
      "statement": "# Gey, Coffman and Kubicek: continuous culture of the HeLa cervical-carcinoma strain\n\nReported an in-vitro comparison of cervical tissues and described one epidermoid-carcinoma strain maintained in continuous roller-tube culture for almost a year.\n\n## Scientific scope\n\nThe record is the exact 1952 Cancer Research proceedings paper. Henrietta Lacks’s tissue contribution, the absence of her knowledge or consent, later HeLa distribution, cell-line applications and subsequent discoveries remain separate.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nGeorge Otto Gey; Ward D. Coffman; Mary Toye Kubicek\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [Cellosaurus publication record for Gey, Coffman and Kubicek](https://www.cellosaurus.org/cellopub/CLPUB00047)\n- [Cancer Research volume 12 issue 4](https://aacrjournals.org/cancerres/issue/12/4)\n- [NIH–Lacks Family Agreement and HeLa history](https://www.grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/dms/privacy/nih-lacks-family-agreement)\n",
      "summary": "Reported an in-vitro comparison of cervical tissues and described one epidermoid-carcinoma strain maintained in continuous roller-tube culture for almost a year.",
      "title": "Gey, Coffman and Kubicek: continuous culture of the HeLa cervical-carcinoma strain"
    },
    "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
    "version": 1,
    "source_ref": {
      "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
      "version": 1,
      "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
    },
    "export_view": "wrs-public-editorial-view-1",
    "public_view_hash": "sha256:127eb452637621dd99be03764c6bcc828c8e64fca1a3feecb30a639d0e00b774"
  },
  "target": {
    "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
    "version": 1,
    "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
  },
  "published_grade": {
    "profile": "wrs-published-grade-1",
    "edition": "2026-10-28.1",
    "id": "gey-hela-continuous-cell-culture-1952",
    "entry_id": "gey-hela-continuous-cell-culture-1952",
    "revision": 1,
    "title": "Gey, Coffman and Kubicek: continuous culture of the HeLa cervical-carcinoma strain",
    "context": "Cell biology",
    "track": "Research resource",
    "band": "A",
    "modifier": "+",
    "status": "PROVISIONAL_EDITORIAL",
    "assessed_on": "2026-09-25",
    "evidence_cutoff": "2026-09-25",
    "achievement_state": "SUPPORTED_SCOPED_RESULT",
    "what_changed": "A continuously propagating human cancer-cell strain was available for laboratory research.",
    "scope": "Gey, Coffman and Kubicek's 1952 note; tissue donor Henrietta Lacks, later distribution and uses distinct.",
    "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact 1952 Cancer Research proceedings paper. Henrietta Lacks’s tissue contribution, the absence of her knowledge or consent, later HeLa distribution, cell-line applications and subsequent discoveries remain separate.",
    "references": [
      {
        "title": "Cellosaurus publication record for Gey, Coffman and Kubicek",
        "url": "https://www.cellosaurus.org/cellopub/CLPUB00047",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      },
      {
        "title": "Cancer Research volume 12 issue 4",
        "url": "https://aacrjournals.org/cancerres/issue/12/4",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      },
      {
        "title": "NIH–Lacks Family Agreement and HeLa history",
        "url": "https://www.grants.nih.gov/policy-and-compliance/policy-topics/sharing-policies/dms/privacy/nih-lacks-family-agreement",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      }
    ],
    "roles": [
      {
        "who": "George Otto Gey",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Ward D. Coffman",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Mary Toye Kubicek",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      }
    ],
    "target": {
      "record_id": "urn:uuid:0ddbaffa-5764-4073-a8e4-543ad4f5bb67",
      "version": 1,
      "content_hash": "sha256:e05eb8476209540b86fb3a8e36161e826c0bbb41dc5ef466f8c64595192508ce"
    },
    "scientific_correctness_certified": false,
    "independent_expert_calibration": false,
    "method": "PROPRIETARY",
    "points": "165000"
  },
  "canonical_agent_submission": false,
  "scientific_verification_awarded": false,
  "reader_guide": null,
  "reading_status": "SOURCE_LINKED_NOTE"
}