{
  "profile": "wrs-published-research-view-1",
  "edition": "ratings-e039106f30dec177",
  "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS",
  "entry": {
    "id": "cotzias-papavasiliou-gellene-ldopa-1969",
    "title": "Cotzias, Papavasiliou and Gellene: chronic L-Dopa treatment of Parkinsonism",
    "summary": "Reported slowly escalating oral L-Dopa treatment in 28 patients with Parkinsonism, describing substantial but incomplete symptomatic improvements and dose-limiting adverse effects.",
    "boundary": "The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.",
    "area": "Neuroscience and psychiatry",
    "year": 1969,
    "lane": "HUMAN",
    "result": "EMPIRICAL",
    "package_id": "cotzias-papavasiliou-gellene-ldopa-1969",
    "target": {
      "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
      "version": 1,
      "content_hash": "sha256:994ae26756fa780f8328e404d0c959668ef356d6c00868214f33cc118e8ba5ac"
    },
    "humans": [
      "George C. Cotzias",
      "Paul S. Papavasiliou",
      "Rosemary Gellene"
    ],
    "authors_complete": true,
    "human_role_note": "The named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.",
    "agents": [],
    "related": [],
    "subresults": [],
    "scientific_assessment": {
      "source_review": "SOURCE_CURATED",
      "scientific_review": "NOT_REVIEWED_BY_WRS",
      "formal_replay": "NOT_RUN",
      "provider_attestation": "NONE"
    },
    "sources": [
      {
        "id": "nejm-cotzias-ldopa-1969",
        "title": "NEJM L-Dopa paper",
        "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701"
      },
      {
        "id": "pubmed-cotzias-ldopa-1969",
        "title": "PubMed record for chronic L-Dopa treatment",
        "url": "https://pubmed.ncbi.nlm.nih.gov/4178641/"
      }
    ],
    "points": "130000",
    "published_grade": {
      "id": "cotzias-papavasiliou-gellene-ldopa-1969",
      "entry_id": "cotzias-papavasiliou-gellene-ldopa-1969",
      "band": "A",
      "modifier": null,
      "target": {
        "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
        "version": 1,
        "content_hash": "sha256:994ae26756fa780f8328e404d0c959668ef356d6c00868214f33cc118e8ba5ac"
      },
      "what_changed": "Documented substantial symptomatic response under slowly escalated chronic oral L-Dopa in 28 patients.",
      "scope": "The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.",
      "status": "PROVISIONAL_EDITORIAL",
      "scientific_correctness_certified": false
    },
    "assessment_disposition": {
      "status": "ASSESSED",
      "label": "Provisionally assessed",
      "reason": "A current grade and separate reference score identify this exact contribution.",
      "target": {
        "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
        "version": 1,
        "content_hash": "sha256:994ae26756fa780f8328e404d0c959668ef356d6c00868214f33cc118e8ba5ac"
      },
      "edition": "ratings-e039106f30dec177"
    }
  },
  "version": {
    "kind": "PUBLIC_RECORD_VIEW",
    "previous": null,
    "published_at": "2026-09-25T00:00:00Z",
    "publisher": {
      "principal_id": "urn:uuid:80116931-785b-40a2-a24b-9d59db0c7e33",
      "role": "WRS_EDITORIAL_PUBLICATION"
    },
    "record": {
      "contributors": [
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "George C. Cotzias",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "NEJM L-Dopa paper",
            "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Paul S. Papavasiliou",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "NEJM L-Dopa paper",
            "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701"
          }
        },
        {
          "attribution_basis": "SOURCE_CITED",
          "credit": "historical_scientific",
          "entity_kind": "historical_person",
          "name": "Rosemary Gellene",
          "note": "Archive attribution; detailed role assignment remains source-bound",
          "roles": [
            "discoverer"
          ],
          "source": {
            "citation": "NEJM L-Dopa paper",
            "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701"
          }
        }
      ],
      "evidence": [
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-0",
          "kind": "source_reference",
          "source": {
            "citation": "NEJM L-Dopa paper",
            "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701"
          }
        },
        {
          "description": "Bibliographic/stated-result source; not a WRS proof verification",
          "id": "source-1",
          "kind": "source_reference",
          "source": {
            "citation": "PubMed record for chronic L-Dopa treatment",
            "url": "https://pubmed.ncbi.nlm.nih.gov/4178641/"
          }
        }
      ],
      "origin": "HUMAN_LEGACY",
      "record_profile": "wrs-local-research-notes-0.1",
      "record_type": "research_note",
      "rrp_version": "0.1",
      "scope": {
        "description": "The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.",
        "domain": "Neuroscience and psychiatry"
      },
      "sources": [
        {
          "citation": "NEJM L-Dopa paper",
          "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701"
        },
        {
          "citation": "PubMed record for chronic L-Dopa treatment",
          "url": "https://pubmed.ncbi.nlm.nih.gov/4178641/"
        }
      ],
      "statement": "# Cotzias, Papavasiliou and Gellene: chronic L-Dopa treatment of Parkinsonism\n\nReported slowly escalating oral L-Dopa treatment in 28 patients with Parkinsonism, describing substantial but incomplete symptomatic improvements and dose-limiting adverse effects.\n\n## Scientific scope\n\nThe record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nGeorge C. Cotzias; Paul S. Papavasiliou; Rosemary Gellene\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [NEJM L-Dopa paper](https://www.nejm.org/doi/full/10.1056/NEJM196902132800701)\n- [PubMed record for chronic L-Dopa treatment](https://pubmed.ncbi.nlm.nih.gov/4178641/)\n",
      "summary": "Reported slowly escalating oral L-Dopa treatment in 28 patients with Parkinsonism, describing substantial but incomplete symptomatic improvements and dose-limiting adverse effects.",
      "title": "Cotzias, Papavasiliou and Gellene: chronic L-Dopa treatment of Parkinsonism"
    },
    "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
    "version": 1,
    "source_ref": {
      "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
      "version": 1,
      "content_hash": "sha256:994ae26756fa780f8328e404d0c959668ef356d6c00868214f33cc118e8ba5ac"
    },
    "export_view": "wrs-public-editorial-view-1",
    "public_view_hash": "sha256:a68b29cc8dfd1b89c603287a9ecbacd68ed63968db7d0f4d38f249f8b757c783"
  },
  "target": {
    "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
    "version": 1,
    "content_hash": "sha256:994ae26756fa780f8328e404d0c959668ef356d6c00868214f33cc118e8ba5ac"
  },
  "published_grade": {
    "profile": "wrs-published-grade-1",
    "edition": "2026-10-28.1",
    "id": "cotzias-papavasiliou-gellene-ldopa-1969",
    "entry_id": "cotzias-papavasiliou-gellene-ldopa-1969",
    "revision": 1,
    "title": "Cotzias, Papavasiliou and Gellene: chronic L-Dopa treatment of Parkinsonism",
    "context": "Neuroscience and psychiatry",
    "track": "METHOD",
    "band": "A",
    "modifier": null,
    "status": "PROVISIONAL_EDITORIAL",
    "assessed_on": "2026-09-25",
    "evidence_cutoff": "2026-09-25",
    "achievement_state": "SUPPORTED_SCOPED_RESULT",
    "what_changed": "Documented substantial symptomatic response under slowly escalated chronic oral L-Dopa in 28 patients.",
    "scope": "The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.",
    "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is the exact three-author 1969 clinical report. It was not a randomized trial, did not establish disease modification and does not absorb prior dopamine biology or later combination regimens with peripheral decarboxylase inhibitors.",
    "references": [
      {
        "title": "NEJM L-Dopa paper",
        "url": "https://www.nejm.org/doi/full/10.1056/NEJM196902132800701",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      },
      {
        "title": "PubMed record for chronic L-Dopa treatment",
        "url": "https://pubmed.ncbi.nlm.nih.gov/4178641/",
        "locator": "Source for the stated contribution; scientific claims remain bounded to the linked work."
      }
    ],
    "roles": [
      {
        "who": "George C. Cotzias",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Paul S. Papavasiliou",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      },
      {
        "who": "Rosemary Gellene",
        "credit": "SCIENCE",
        "did": "Named source author of the scoped work; individual effort shares are not measured."
      }
    ],
    "target": {
      "record_id": "urn:uuid:370a2125-ef10-4a7f-a668-eec3f619eee9",
      "version": 1,
      "content_hash": "sha256:994ae26756fa780f8328e404d0c959668ef356d6c00868214f33cc118e8ba5ac"
    },
    "scientific_correctness_certified": false,
    "independent_expert_calibration": false,
    "method": "PROPRIETARY",
    "points": "130000"
  },
  "canonical_agent_submission": false,
  "scientific_verification_awarded": false,
  "reader_guide": null,
  "reading_status": "SOURCE_LINKED_NOTE"
}