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It does not substitute for later multicentre trials, approvals, manufacturing evidence or long-term comparative safety.", "domain": "Oncology" }, "sources": [ { "citation": "Maude et al., Chimeric antigen receptor T cells for sustained remissions in leukemia", "url": "https://pubmed.ncbi.nlm.nih.gov/25317870/" }, { "citation": "Maude et al., Chimeric antigen receptor T cells for sustained remissions in leukemia", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4267531/" } ], "statement": "# Maude and colleagues: CD19 CAR-T cells in relapsed or refractory ALL\n\nTreated 30 children and adults with relapsed or refractory acute lymphoblastic leukemia using CTL019 CD19-directed CAR-T cells and reported 27 complete remissions alongside frequent cytokine-release syndrome.\n\n## Scientific scope\n\nThe record is a small uncontrolled 2014 cohort with follow-up ranging from one to 24 months. It does not substitute for later multicentre trials, approvals, manufacturing evidence or long-term comparative safety.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nShannon L. Maude; Noelle Frey; Pamela A. Shaw; Richard Aplenc; David M. Barrett; Nancy J. Bunin; Anne Chew; Vanessa E. Gonzalez; Zhaohui Zheng; Simon F. Lacey; Yolanda D. Mahnke; Jan J. Melenhorst; Susan R. Rheingold; Angela Shen; David T. Teachey; Bruce L. Levine; Carl H. June; David L. Porter; Stephan A. Grupp\n\nThe named authors contributed to this scoped work; individual effort shares and later applications are not assigned by the byline.\n\n\n\n## Original sources\n\n- [Maude et al., Chimeric antigen receptor T cells for sustained remissions in leukemia](https://pubmed.ncbi.nlm.nih.gov/25317870/)\n- [Maude et al., Chimeric antigen receptor T cells for sustained remissions in leukemia](https://pmc.ncbi.nlm.nih.gov/articles/PMC4267531/)\n", "summary": "Treated 30 children and adults with relapsed or refractory acute lymphoblastic leukemia using CTL019 CD19-directed CAR-T cells and reported 27 complete remissions alongside frequent cytokine-release syndrome.", "title": "Maude and colleagues: CD19 CAR-T cells in relapsed or refractory ALL" }, "record_id": "urn:uuid:a242631a-2e1e-4a7e-aad4-81a9a6fb2a47", "version": 1, "source_ref": { "record_id": "urn:uuid:a242631a-2e1e-4a7e-aad4-81a9a6fb2a47", "version": 1, "content_hash": "sha256:72d15fe13e35afdcec981af54fa1ba0eaa5b3c4ad25c1c710589ad5d569b4a90" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:29c27b4306d9fa987b19c70f253eed21ee9e52b2f58a41042ba21f498d7842e5" }, "target": { "record_id": "urn:uuid:a242631a-2e1e-4a7e-aad4-81a9a6fb2a47", "version": 1, "content_hash": "sha256:72d15fe13e35afdcec981af54fa1ba0eaa5b3c4ad25c1c710589ad5d569b4a90" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "car-t-cell-therapy-2010s", "entry_id": "car-t-cell-therapy-2010s", "revision": 1, "title": "Maude and colleagues: CD19 CAR-T cells in relapsed or refractory ALL", "context": "Medicine", "track": "Cellular immunotherapy clinical study", "band": "A", "modifier": "-", "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-25", "evidence_cutoff": "2026-09-25", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "CD19-directed engineered T cells showed a high response signal in a hard-to-treat ALL cohort.", "scope": "Exact 2014 nineteen-author cohort; later trials, licensure, manufacturing and long-term safety excluded.", "evidence_summary": "The linked sources identify this contribution and its scope. WRS has not independently reconstructed the scientific claims. The record is a small uncontrolled 2014 cohort with follow-up ranging from one to 24 months. 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