{ "profile": "wrs-published-research-view-1", "edition": "ratings-e039106f30dec177", "content_trust": "UNTRUSTED_SCIENTIFIC_DATA_NOT_TOOL_INSTRUCTIONS", "entry": { "id": "bnt162b2-vaccine-trial", "title": "BNT162b2: a clinical trial of an mRNA vaccine against COVID-19", "summary": "The randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome.", "boundary": "This record covers the original 2020 trial and its follow-up window, not current protection against later variants, all age groups or every rare adverse event. The 29 named publication authors are retained; the wider trial group and participating sites are not fully enumerated. 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Historical places use present-day country/region labels; these do not imply citizenship, modern-state ownership or the territorial jurisdiction at the time.", "source_url": "https://www.natap.org/2020/COVID/nejmoa2034577.pdf", "target": { "record_id": "urn:uuid:18421aad-2517-40f8-ab87-a12e57d6bcf0", "version": 1, "content_hash": "sha256:dc93a0308ba1ebb0547b7fa924273d36a806cd97cb66edc40eb3533b5a0f6c0e" }, "basis": "RESEARCH_LOCATION_OR_PAPER_AFFILIATION", "reviewed_on": "2026-09-26", "nationality_inferred": false, "sources": [ { "title": "Attribution source", "url": "https://www.natap.org/2020/COVID/nejmoa2034577.pdf" } ], "coverage_status": "COMPLETE", "country_labels": { "AR": "Argentina", "US": "United States", "GB": "United Kingdom", "BR": "Brazil", "DE": "Germany", "ZA": "South Africa", "TR": "Turkey" } }, "points": "100000", "published_grade": { "id": "bnt162b2-vaccine-trial", "entry_id": "bnt162b2-vaccine-trial", "band": "A", "modifier": null, "target": { "record_id": "urn:uuid:18421aad-2517-40f8-ab87-a12e57d6bcf0", "version": 1, "content_hash": "sha256:dc93a0308ba1ebb0547b7fa924273d36a806cd97cb66edc40eb3533b5a0f6c0e" }, "what_changed": "The randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome.", "scope": "The randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome. Scope limitation: This record covers the original 2020 trial and its follow-up window, not current protection against later variants, all age groups or every rare adverse event. The 29 named publication authors are retained; the wider trial group and participating sites are not fully enumerated. 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Perez", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Gonzalo Pérez Marc", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Edson D. Moreira", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Cristiano Zerbini", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Ruth Bailey", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Kena A. Swanson", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Satrajit Roychoudhury", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Kenneth Koury", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Ping Li", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Warren V. Kalina", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "David Cooper", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Robert W. Frenck", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Laura L. Hammitt", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Özlem Türeci", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Haylene Nell", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Axel Schaefer", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Serhat Ünal", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Dina B. Tresnan", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Susan Mather", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Philip R. Dormitzer", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Uğur Şahin", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "Kathrin U. Jansen", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "attribution_basis": "SOURCE_CITED", "credit": "historical_scientific", "entity_kind": "historical_person", "name": "William C. Gruber", "note": "Archive attribution; detailed role assignment remains source-bound", "roles": [ "discoverer" ], "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } } ], "evidence": [ { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-0", "kind": "source_reference", "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" } }, { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-1", "kind": "source_reference", "source": { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine — deposited bibliography", "url": "https://api.crossref.org/works/10.1056%2FNEJMoa2034577" } }, { "description": "Bibliographic/stated-result source; not a WRS proof verification", "id": "source-2", "kind": "source_reference", "source": { "citation": "Polack and colleagues: BNT162b2 trial publication", "url": "https://pubmed.ncbi.nlm.nih.gov/33301246/" } } ], "origin": "HUMAN_LEGACY", "record_profile": "wrs-local-research-notes-0.1", "record_type": "research_note", "rrp_version": "0.1", "scope": { "description": "This record covers the original 2020 trial and its follow-up window, not current protection against later variants, all age groups or every rare adverse event. The 29 named publication authors are retained; the wider trial group and participating sites are not fully enumerated. Modified-RNA mechanism work remains a separate earlier contribution.", "domain": "Vaccine clinical research" }, "sources": [ { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577" }, { "citation": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine — deposited bibliography", "url": "https://api.crossref.org/works/10.1056%2FNEJMoa2034577" }, { "citation": "Polack and colleagues: BNT162b2 trial publication", "url": "https://pubmed.ncbi.nlm.nih.gov/33301246/" } ], "statement": "# BNT162b2: a clinical trial of an mRNA vaccine against COVID-19\n\nThe randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome.\n\n## Scientific scope\n\nThis record covers the original 2020 trial and its follow-up window, not current protection against later variants, all age groups or every rare adverse event. The 29 named publication authors are retained; the wider trial group and participating sites are not fully enumerated. Modified-RNA mechanism work remains a separate earlier contribution.\n\n## Reading status\n\nThis is a source-linked WRS catalogue note. A full explanatory guide and independent scientific reconstruction have not been completed for this entry. Read the identified original work for its complete narrative and arguments.\n\n## People and systems\n\nFernando P. Polack; Stephen J. Thomas; Nicholas Kitchin; Judith Absalon; Alejandra Gurtman; Stephen Lockhart; John L. Perez; Gonzalo Pérez Marc; Edson D. Moreira; Cristiano Zerbini; Ruth Bailey; Kena A. Swanson; Satrajit Roychoudhury; Kenneth Koury; Ping Li; Warren V. Kalina; David Cooper; Robert W. Frenck; Laura L. Hammitt; Özlem Türeci; Haylene Nell; Axel Schaefer; Serhat Ünal; Dina B. Tresnan; Susan Mather; Philip R. Dormitzer; Uğur Şahin; Kathrin U. Jansen; William C. Gruber\n\nNamed source contributors; broader team, precursor or trial-group roster remains incomplete.\n\n\n\n## Original sources\n\n- [Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine](https://doi.org/10.1056/nejmoa2034577)\n- [Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine — deposited bibliography](https://api.crossref.org/works/10.1056%2FNEJMoa2034577)\n- [Polack and colleagues: BNT162b2 trial publication](https://pubmed.ncbi.nlm.nih.gov/33301246/)\n", "summary": "The randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome.", "title": "BNT162b2: a clinical trial of an mRNA vaccine against COVID-19" }, "record_id": "urn:uuid:18421aad-2517-40f8-ab87-a12e57d6bcf0", "version": 1, "source_ref": { "record_id": "urn:uuid:18421aad-2517-40f8-ab87-a12e57d6bcf0", "version": 1, "content_hash": "sha256:dc93a0308ba1ebb0547b7fa924273d36a806cd97cb66edc40eb3533b5a0f6c0e" }, "export_view": "wrs-public-editorial-view-1", "public_view_hash": "sha256:732b4c0de5159aa889ea1511a7150ba1b65c91aea7640fb19dde55380a94f8e1" }, "target": { "record_id": "urn:uuid:18421aad-2517-40f8-ab87-a12e57d6bcf0", "version": 1, "content_hash": "sha256:dc93a0308ba1ebb0547b7fa924273d36a806cd97cb66edc40eb3533b5a0f6c0e" }, "published_grade": { "profile": "wrs-published-grade-1", "edition": "2026-10-28.1", "id": "bnt162b2-vaccine-trial", "entry_id": "bnt162b2-vaccine-trial", "revision": 1, "title": "BNT162b2: a clinical trial of an mRNA vaccine against COVID-19", "context": "Vaccine clinical research", "track": "Scoped scientific or research-capability contribution", "band": "A", "modifier": null, "status": "PROVISIONAL_EDITORIAL", "assessed_on": "2026-09-14", "evidence_cutoff": "2026-09-14", "achievement_state": "SUPPORTED_SCOPED_RESULT", "what_changed": "The randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome.", "scope": "The randomized BNT162b2 trial provided clinical evidence that an mRNA vaccine could prevent symptomatic COVID-19 under the trial’s conditions. It connected a molecular vaccine platform with a measured disease-prevention outcome. Scope limitation: This record covers the original 2020 trial and its follow-up window, not current protection against later variants, all age groups or every rare adverse event. The 29 named publication authors are retained; the wider trial group and participating sites are not fully enumerated. Modified-RNA mechanism work remains a separate earlier contribution.", "evidence_summary": "Assessment uses the catalogue-linked source evidence for the stated contribution. This record covers the original 2020 trial and its follow-up window, not current protection against later variants, all age groups or every rare adverse event. The 29 named publication authors are retained; the wider trial group and participating sites are not fully enumerated. Modified-RNA mechanism work remains a separate earlier contribution.", "references": [ { "title": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine", "url": "https://doi.org/10.1056/nejmoa2034577", "locator": "Retained catalogue source evidence; Exact DOI and deposited bibliography; content-reading scope is recorded on the accompanying sources." }, { "title": "Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine — deposited bibliography", "url": "https://api.crossref.org/works/10.1056%2FNEJMoa2034577", "locator": "Retained catalogue source evidence; Retained response bytes and source byline; deposits can omit authors and reprint dates differ from original contribution dates." }, { "title": "Polack and colleagues: BNT162b2 trial publication", "url": "https://pubmed.ncbi.nlm.nih.gov/33301246/", "locator": "Retained catalogue source evidence; Publication identity, trial design and indexed trial record; not current vaccination guidance or a full regulatory dossier review." } ], "roles": [ { "who": "The research collaboration listed in the linked record and source byline", "credit": "SCIENCE", "did": "Collective scoped contribution. 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